In patients with type 2 diabetes an inflammatory process is present. This inflammation is due to a pathological activation of the innate immune system, caused by metabolic stress and is partly governed by IL-1 signaling. We identified the role of IL-1β and insulin in the regulation of metabolism and immunity in response to food intake. Yet, as it becomes chronic, activation of auto-inflammatory processes may then become deleterious.
As a possible causal therapy, inflammatory mediators may help. This is supported by clinical studies showing that IL-1 antagonism decreases glycated hemoglobin. Furthermore, IL-1 antagonism prevents heart failure and cardiovascular diseases, the major complications of diabetes and may also prevent microvascular complications.
Lecture will cover the pathogenesis of type 2 diabetes, overview of current treatment protocols and potential of future anti-inflammatory treatment, including impact on periodontitis.
Tribune Group GmbH is an ADA CERP Recognized Provider.
ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. Tribune Group designates this activity for 1 continuing education credits.
This continuing education activity has been planned and implemented in accordance with the standards of the ADA Continuing Education Recognition Program (ADA CERP) through joint efforts between Tribune Group GmbH and Dental Tribune International GmbH.
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